The American Mastiff was developed over many years of selective breeding by Fredericka Wagner of Flying W Farms, Piketon, Ohio. The goal was to develop a dog that had the size, temperament, disposition, and the appearance of the Mastiff, but with fewer health problems, and much dryer mouth than other mastiff breeds. This was accomplished by crossing the English Mastiff with the Anatolian Mastiff during the early development of the breed. Visit our website today. Email for available puppies and upcoming litters.