Is she spayed, or unaltered? Has she been in heat lately? Unaltered Great Danes, more often than most, go through false pregnanacies after their heat. She sounds to me as though she is in a false pregnancy, and fussing over her (toy) puppies. Do be sure she is actually eating and drinking in sufficient amounts each day, and not fussing too much. You may need to remove the toys she is treating as puppies, so her hormones can balance out. Don't let her see you take the toys, and don't hide them in any places she can find them; till this possible false pregnancy is over.
If she IS spayed, then it might help to bring her in for a blood test to check her hormone levels, and thyroid levels. She may have some thyroid issues.
Answered by BlueRidgeDandT - 12/3/2013 2:18:35 PM